Apalachicola () is a city in Franklin County, Florida, United States, on the shore of Apalachicola Bay, an inlet of the Gulf of Mexico. The population was 2,231 at the 2010 census. Apalachicola is the county seat of Franklin County.
"Apalachicola" comes from the Apalachicola tribe and is a combination of the Hitchiti words apalahchi, meaning "on the other side", and okli, meaning "people". In original reference to the settlement and the subgroup within the Seminole tribe, it probably meant "people on the other side of the river". Many inhabitants of Apalachicola have said the name means "land of the friendly people".
A British trading post called "Cottonton" was founded at this site on the mouth of the Apalachicola River. Gradually after acquisition by the United States and related development in Alabama and Georgia, it attracted more permanent European-American residents. In 1827, the town was incorporated as "West Point". Apalachicola received its current name in 1831, by an act of the Legislative Council of the Territory of Florida.
Trinity Episcopal Church was incorporated by an act of the Legislative Council of the Territory of Florida on February 11, 1837. The building was one of the earliest prefabricated buildings in the United States.