Berlin is a town in Worcester County, Maryland, United States which includes its own historical Berlin Commercial District. The population was 4,485 at the 2010 census, and has since grown in population. It is part of the Salisbury, Maryland-Delaware Metropolitan Statistical Area.
The town of Berlin lies over land that was originally the 300-acre Burley Plantation, patented by William Tomkins in 1677. With the development of ancient Native American migratory and hunting trails into colonial highways, the Burley Plantation became a crossroads of a post road leading to Philadelphia (today's Main Street) and the Sinepuxent Road. Berlin developed in the early-19th century at this crossroads, where a tavern, blacksmith shop, and livery were among the first established businesses in the new town. Regional tradition asserts that the pronunciation of the town's name, "Burl'in" with emphasis on the first syllable, stems from the "Burley Inn," the early tavern that stood at the crossroads of the Philadelphia Post and Sinepuxent Roads.
Soon after the Civil War, Berlin was incorporated as a town in 1868 and a period of significant growth ensued. Within the next decade, the arrival of the Delaware, Maryland, and Virginia Railroad made Berlin into a commercial center for upper Worcester County. After a fire in 1895 leveled a significant portion of the central commercial district, Victorian structures displaying elements of Queen Anne, Italianate, and Second Empire styles were erected along Main Street. The rise of nearby Ocean City as a tourist destination in the early-twentieth century also aided Berlin's economy by making the town a convenient rest stop.