Branchville is a town in Orangeburg County, South Carolina, United States. The population was 1,024 at the 2010 census.
The community was so named because a railroad branch began at the town site.
The Southern Railway Passenger Depot was added to the National Register of Historic Places in 1973.
Branchville is located at 33°15′7″N 80°49′4″W (33.252055, -80.817778).
According to the United States Census Bureau, the town has a total area of 3.3 square miles (8.5 km2), all land.
As of the census of 2000, there were 1,083 people, 446 households, and 276 families residing in the town. The population density was 331.2 people per square mile (127.9/km²). There were 508 housing units at an average density of 155.3 per square mile (60.0/km²). The racial makeup of the town was 54.48% White, 43.12% African American, 0.18% Native American, 0.09% Asian, 1.11% from other races, and 1.02% from two or more races. Hispanic or Latino of any race were 1.39% of the population.
There were 446 households out of which 27.8% had children under the age of 18 living with them, 41.7% were married couples living together, 16.6% had a female householder with no husband present, and 37.9% were non-families. 35.7% of all households were made up of individuals and 15.5% had someone living alone who was 65 years of age or older.