Fulton is a city in and the county seat of Itawamba County, Mississippi, United States. The population was 3,961 at the 2010 census.
The city is part of the Tupelo Micropolitan Statistical Area.
Fulton was established in 1837 as a county seat for the newly-created Itawamba County. It is named for Robert Fulton, inventor of the steamboat.
Fulton is located west of the center of Itawamba County at 34°15′58″N 88°24′5″W (34.266110, -88.401358). It is bordered to the west by the Tennessee–Tombigbee Waterway.
Interstate 22/U.S. Route 78 passes through the southern part of the city, with access from Exit 104 (S. Adams Street). I-22 leads west 19 miles (31 km) to Tupelo and east 25 miles (40 km) to Hamilton, Alabama. Mississippi Highway 25 passes through the southeastern part of Fulton, leading south 14 miles (23 km) to Smithville and north 26 miles (42 km) to Belmont.
According to the United States Census Bureau, Fulton has a total area of 8.7 square miles (22.6 km2), of which 8.5 square miles (22.0 km2) are land and 0.23 square miles (0.6 km2), or 2.46%, are water.
As of the census of 2000, there were 3,882 people, 1,357 households, and 891 families residing in the city. The population density was 450.3 people per square mile (173.9/km²).