Gifford is a town in Hampton County, South Carolina, United States. The population was 288 at the 2010 census, down from 370 at the 2000 census.
Gifford is located in northwestern Hampton County at 32°51′39″N 81°14′20″W (32.860831, -81.238958). U.S. Route 321 (Columbia Highway) passes through the center of town, leading north 7 miles (11 km) to Fairfax and south 3 miles (5 km) to Luray. Hampton, the county seat, is 9 miles (14 km) to the east, and Columbia, the state capital, is 84 miles (135 km) to the north.
According to the United States Census Bureau, the town of Gifford has a total area of 0.97 square miles (2.5 km2), all land.
As of the census of 2000, there were 370 people, 123 households, and 87 families residing in the town. The population density was 393.0 people per square mile (152.0/km²). There were 146 housing units at an average density of 155.1 per square mile (60.0/km²). The racial makeup of the town was 6.22% White, 92.70% African American, and 1.08% from two or more races.
There were 123 households out of which 34.1% had children under the age of 18 living with them, 35.8% were married couples living together, 30.1% had a female householder with no husband present, and 28.5% were non-families.