Greenville (; locally ) is the largest city in and the seat of Greenville County, South Carolina, United States. The city's mayor is Knox H. White, who has been in that position since December 1995. With an estimated population of 68,219 as of 2017, it is the sixth-largest city in the state. The population of the surrounding area was 400,492 as of 2010, making it the third-largest urban area in South Carolina as well as the fastest growing. Greenville is the largest city in the Greenville-Anderson-Mauldin Metropolitan Statistical Area. The MSA had a population of 906,626 in 2018, making it the largest in South Carolina and the third largest in the Carolinas.
Greenville is the largest city in the Greenville-Spartanburg-Anderson Combined Statistical Area, a 10-county region of northwestern South Carolina known as "The Upstate". According to United States Census Bureau, the CSA had a population of 1,478,658 as of 2018, making it the largest CSA in the state. Greenville is located approximately halfway between Atlanta and Charlotte, North Carolina, along Interstate 85, and its metropolitan area also includes Interstates 185 and 385.
Greenville has gained recognition in various national publications such as CNN Money, which ranked Greenville as one of the "Top 10 Fastest Growing Cities in the U.S." Bloomberg named Greenville the Third Strongest Job Market for 2010; and Forbes named Greenville the 13th Best City for Young Professionals.