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Itasca is a village in DuPage County, Illinois, United States. It is located approximately 27 miles northwest of downtown Chicago. It is close to O'Hare International Airport, major expressways, and rail transportation. The population was 8,649 at the 2010 census. In 2009, BusinessWeek rated Itasca as the 'Best Affordable Suburb' in the state of Illinois.
Itasca was first settled by Elijah Smith in 1841. Smith practiced medicine in Boston. In May 1841, at the advice of his colleagues he set out to find a suitable site for doctoring, farming, and raising a family. He traveled from New York via Detroit and headed toward DuPage County. His parchment government land title dated March 10, 1843, was signed by John Tyler, President of the United States. The document gave Smith title to the land that is now bounded by the railroad tracks on the south, Maple Street on the west, Cherry Street on the east, and Division Street on the north.