Lancaster locally is a home rule-class city in Garrard County, Kentucky, in the United States. It is the seat of its county. As of the year 2010 U.S. census, the city population was 3,442.
Located south of Lexington, Lancaster is the site of the Kennedy House, sometimes said to have been the setting for Uncle Tom's Cabin. The Civil War training base Camp Dick Robinson was located nearby.
Lancaster is located west of the center of Garrard County at 37°37′7″N 84°34′46″W (37.618625, -84.579433). U.S. Route 27 passes through the city, leading north 35 miles (56 km) to Lexington and south 39 miles (63 km) to Somerset. Kentucky Route 52 crosses US 27 in the center of Lancaster, leading east and northeast 23 miles (37 km) to Richmond, and west 11 miles (18 km) to Danville. Lancaster is 3 miles (5 km) east of the Dix River, a north-flowing tributary of the Kentucky River.
According to the United States Census Bureau, Lancaster has a total area of 1.9 square miles (5.0 km2), all land.
The climate in this area is characterized by hot, humid summers and generally mild to cool winters. According to the Köppen Climate Classification system, Lancaster has a humid subtropical climate, abbreviated "Cfa" on climate maps.
In 1797, Captain William Buford donated land for the establishment of a town around the site of Major Andrew Wallace's settlement at Wallace Crossroads.