Mantachie is a town in Itawamba County, Mississippi, United States. The population was 1,144 in the 2010 census. It is located 14 miles (23 km) northeast of Tupelo at the intersection of Mississippi Highways 363 and 371 and 5 miles (8 km) north of Interstate 22.
The town began as a crossroads store owned and operated by Woods Pearce. Near Mantachie on the old Jacinto Road was the largest Chickasaw village in this section of the state. Mantachie was named for one of the Chickasaw chiefs, Man-ta-chee. Most of the Chickasaws left the village after the Treaty of Pontotoc Creek was signed in 1832.
The current District 19 state representative, Republican Randy Boyd, resides in Mantachie.
Mantachie is located in western Itawamba County at 34°19′51″N 88°29′36″W. Mantachie Creek, a south-flowing tributary of the Tombigbee River, runs past the west side of the town.