North Fort Myers is an unincorporated area and census-designated place (CDP) in Lee County, Florida, United States. The population was 39,330 at the 2010 census. It is part of the Cape Coral-Fort Myers, Florida Metropolitan Statistical Area.
North Fort Myers is located in northern Lee County at 26°42′N 81°53′W (26.7029, -81.8844), northwest across the Caloosahatchee River from Fort Myers proper. It is bordered to the west by the city of Cape Coral and to the north by Charlotte County.
Interstate 75 runs through North Fort Myers, with access from Exit 143 (Florida State Road 78). I-75 leads northwest 67 miles (108 km) to the Sarasota area and south 38 miles (61 km) to the Naples area, while SR-78 leads east 34 miles (55 km) to LaBelle and west 16 miles (26 km) to Pine Island Center. U.S. Route 41 (North Tamiami Trail) passes through the center of North Fort Myers, leading southeast across the Caloosahatchee Bridge into the center of Fort Myers and northwest 24 miles (39 km) to Port Charlotte.
According to the United States Census Bureau, the North Fort Myers CDP has a total area of 54.4 square miles (140.9 km2), of which 50.6 square miles (131.1 km2) are land and 3.8 square miles (9.8 km2), or 6.97%, are water.
As of the census of 2010, there were 39,330 people, 19,781 households, and 11,727 families residing in the CDP. The population density was 777.0 people per square mile (300.0/km²). There were 27,046 housing units, of which 7,265, or 26.9%, were vacant.