Ste. Genevieve (French: Sainte-Geneviève [sɛ̃t ʒən.vjɛv]) is a city in Ste. Genevieve Township and is the county seat of Ste. Genevieve County, Missouri, United States. The population was 4,410 at the 2010 census. Founded in 1735 by French Canadian colonists and settlers from east of the river, it was the first organized European settlement west of the Mississippi River in present-day Missouri. Today, it is home to Ste. Genevieve National Historical Park, the 422nd unit of the National Park Service.
Founded around 1740 by Canadien settlers and migrants from settlements in the Illinois Country just east of the Mississippi River, Ste. Geneviève is the oldest permanent European settlement in Missouri.