Smoaks is a town in Colleton County, South Carolina, United States. The population was 126 at the 2010 census.
Smoaks is located in northern Colleton County at 33°05′27″N 80°48′39″W. U.S. Route 21 passes through the town, leading north 28 miles (45 km) to Orangeburg and south 31 miles (50 km) to Yemassee. Walterboro, the Colleton County seat, is 18 miles (29 km) to the southeast via US 21 and South Carolina Highway 64. South Carolina Highway 217 crosses US 21 in the center of Smoaks, leading west 8 miles (13 km) to Lodge and east 11 miles (18 km) to Interstate 95 near Canadys.
According to the United States Census Bureau, Smoaks has a total area of 1.6 square miles (4.2 km2), all land.
As of the census of 2000, there were 140 people, 59 households, and 41 families residing in the town. The population density was 85.9 people per square mile (33.2/km2). There were 68 housing units at an average density of 41.7 per square mile (16.1/km2). The racial makeup of the town was 85.71% White, 11.43% African American, and 2.86% from two or more races.
There were 59 households out of which 28.8% had children under the age of 18 living with them, 57.6% were married couples living together, 6.8% had a female householder with no husband present, and 30.5% were non-families.