South Berwick is a town in York County, Maine, United States. The population was 7,220 at the 2010 census. South Berwick is home to Berwick Academy, a private, co-educational university-preparatory day school founded in 1791.
The town was set off from Berwick in 1814, followed by North Berwick in 1831. It is part of the Portland–South Portland–Biddeford, Maine metropolitan statistical area.
The area was called Newichawannock by the Abenaki Indians, meaning "river with many falls," a reference to the Salmon Falls River. It was first settled by Europeans about 1631 as a part of Kittery known as Kittery North Parish. Near the confluence with the Great Works River, Ambrose Gibbons built the Great House at Newichawannock, a palisaded trading post, to exchange goods with the Indians.
In 1634, William Chadbourne, James Wall, and John Goddard arrived from England aboard the ship Pied Cow to build a sawmill and gristmill at Assabumbadoc Falls. The first houses built in South Berwick were built by Chadbourne and Wall.