Toughkenamon is a census-designated place (CDP) in New Garden Township, Chester County, Pennsylvania, United States. The population was 1,492 at the 2010 census.
The area known as Toughkenamon was originally inhabited by Lenape Native Americans who spoke Unami. In the original survey, in 1700, the surveyor notes that he crossed the Dochcanamon Hill. Other forms of spelling this name were used, such as Tokenamon, Taukenamon, Taughlikenemon.
Thomas and Mary Rowland settled in the valley, near the present village of Toughkenamon, in 1706, being perhaps the first settlers who purchased lands in New Garden Township. They came to the township from old Ashton Township, old Chester County, now in Delaware County.
Toughkenamon has been of significant importance in the development of the United States. First, the characteristics of the interactions between settlers and Lenapes was a microcosm of the conflicts that would occur in the future. For example, the farmers dug trenches around their crops, and filled them with water, to prevent reoccurrence of the conflagration that occurred when local Lenapes started a burn.