Upton is a town in Weston County, Wyoming, United States. The population was 1,100 at the 2010 census. The slogan for the town is "The best town on earth".
Upton is located at 44°6′12″N 104°37′33″W (44.103354, -104.625943). According to the United States Census Bureau, the town has a total area of 2.96 square miles (7.67 km2), all of it land.
Upton is home to an abundance of wildlife. Nearby are lakes and streams with many fish species.
As of the 2010 United States Census of 2010, there were 1,100 people, 467 households, and 303 families residing in the town. The population density was 371.6 inhabitants per square mile (143.5/km2). There were 539 housing units at an average density of 182.1 per square mile (70.3/km2). The racial makeup of the town was 95.6% White, 0.2% African American, 1.7% Native American, 0.5% Asian, 0.7% from other races, and 1.3% from two or more races. Hispanic or Latino of any race were 2.3% of the population.