Brentford is a town in Spink County, South Dakota, United States. The population was 77 at the 2010 census.
The town took its name after Brentford, in England, the native home of a railroad official.
Brentford is located at 45°9′33″N 98°19′24″W (45.159216, -98.323267).
According to the United States Census Bureau, the town has a total area of 0.16 square miles (0.41 km2), all land.
Brentford has been assigned the ZIP code 57429, and the FIPS place code 07060.
As of the census of 2010, there were 77 people, 30 households, and 19 families residing in the town. The population density was 481.3 inhabitants per square mile (185.8/km2). There were 33 housing units at an average density of 206.3 per square mile (79.7/km2). The racial makeup of the town was 98.7% White and 1.3% from two or more races.
There were 30 households, of which 30.0% had children under the age of 18 living with them, 53.3% were married couples living together, 10.0% had a female householder with no husband present, and 36.7% were non-families. 23.3% of all households were made up of individuals, and 6.7% had someone living alone who was 65 years of age or older. The average household size was 2.57 and the average family size was 3.00.