Carlisle is a city in Lonoke County, Arkansas, United States. It is the easternmost municipality within the Little Rock–North Little Rock–Conway Metropolitan Statistical Area. Carlisle was incorporated in 1878. As of the 2010 census it had a population of 2,214.
Carlisle is located in eastern Lonoke County at 34°47′10″N 91°44′41″W (34.786109, -91.744835). Interstate 40 passes through the northern side of the city, with access from Exit 183 (Highway 13). I-40 leads east 57 miles (92 km) to Forrest City and west 29 miles (47 km) to North Little Rock. U.S. Route 70 passes through the center of Carlisle as Park Street and serves as a local highway parallel to I-40. US-70 leads east 9 miles (14 km) to Hazen and west the same distance to Lonoke, the county seat. Arkansas Highway 13 passes through the west side of Carlisle and leads north 16 miles (26 km) to Hickory Plains and south 17 miles (27 km) to Humnoke.
According to the United States Census Bureau, Carlisle has a total area of 4.9 square miles (13 km2), of which 4.9 square miles (13 km2) are land and 0.04 square miles (0.10 km2), or 0.48%, are water.