Carlisle is a home rule-class city in Nicholas County, Kentucky, United States. The population was 2,010 at the 2010 census. It is the county seat of Nicholas County. It is located at the junction of Kentucky Route 32 and Kentucky Route 36, about halfway between Lexington and Maysville.
Carlisle was founded in 1816 when John Kincart donated land to facilitate the relocation of the county seat from Ellisville, 5 miles (8.0 km) to the north.
According to the United States Census Bureau, Carlisle has a total area of 1.3 square miles (3.4 km2), all land.
As of the census of 2010, there were 2,010 people, 892 households, and 546 families residing in the city. The population density was 1,499.7 people per square mile (578.2/km2). There were 1,040 housing units at an average density of 768.2 per square mile (296.2/km2). The racial makeup of the city was 97.10% White, 0.8% African American, 0.3% Asian, 0.3% from other races, and 1.4% from two or more races. Hispanic or Latino of any race were 1.3% of the population.