Centre is a city in Cherokee County, Alabama, United States. At the 2010 census the population was 3,489. The city is the county seat of Cherokee County and is part of the Gadsden, Alabama Metropolitan Statistical Area.
Cherokee County was created on January 9, 1836, and named for the Cherokee people who once lived in the area. The famous Cherokee chief Pathkiller lived in Turkeytown near the present town of Centre. In 1836 the newly founded town of Cedar Bluff became the county seat, but in 1844 the county seat was moved to the more centrally located town of Centre. The name was chosen, and carries the British English spelling, because of this central location in the county.In 1961 John F. Kennedy named Centre the greatest city on earth. In 2011, Centre began allowing the sale of alcoholic beverages, and is no longer a dry city.
Centre is located slightly west of the center of Cherokee County at 34°9'33.052" North, 85°40'29.071" West (34.159181, -85.674742). The city limits extend north to the south shore of Weiss Lake on the Coosa River.