Clayton is a town in northern Concordia Parish, Louisiana, United States. The population was 711 at the 2010 census. Cotton is a principal commodity in the area. Clayton is located on the Tensas River, important for fishing and boating, promoted through a U.S. Army Corps of Engineers-maintained boat launch. The Tensas River merges with the Black River in Jonesville in Catahoula Parish.
Louisiana State Representative Andy Anders is from Clayton and Ferriday.
Among the businesses in the community are Cross Keys Bank and David's Grocery.
A major employer in the town was Clayton Gin Company which closed in the early 2000s and was mostly demolished in the early 2010s. The Clayton Gin was originally constructed in the 1940s by W. Howard Davis and his brother Doyle E. Davis. The gin operated under the name "Davis Bros.