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East Petersburg is a borough in Lancaster County, Pennsylvania, United States. The population was 4,506 at the 2010 census.
East Petersburg is located in north-central Lancaster County at 40°6′0″N 76°21′10″W (40.100079, -76.352649). Pennsylvania Route 72 is the borough's Main Street, leading northwest 5 miles (8 km) to Manheim and southeast the same distance to the center of Lancaster. Pennsylvania Route 722 (State Street) crosses Main Street in the center of town, and leads east 3 miles (5 km) to Neffsville and southwest 1.8 miles (2.9 km) to an interchange with the Pennsylvania Route 283 freeway.
According to the United States Census Bureau, the borough has a total area of 1.2 square miles (3.1 km2), all of it land.
As of the census of 2000, there were 4,450 people, 1,708 households, and 1,327 families residing in the borough. The population density was 3,688.6 people per square mile (1,420.0/km²). There were 1,766 housing units at an average density of 1,463.8 per square mile (563.5/km²). The racial makeup of the borough was 95.03% White, 1.35% Black or African American, 0.16% Native American, 1.10% Asian, 0.07% Pacific Islander, 1.17% from other races, and 1.12% from two or more races. 2.85% of the population were Hispanic or Latino of any race.
There were 1,708 households, out of which 34.4% had children under the age of 18 living with them, 64.5% were married couples living together, 9.5% had a female householder with no husband present, and 22.3% were non-families.