Gadsden is a town in Crockett County, Tennessee, United States. The population was 470 at the 2010 census. It is the birthplace of Hall of Fame rock guitarist Scotty Moore, who played with Elvis Presley and Ricky Nelson.
Gadsden was established in the mid-19th century as a stop along the Memphis, Clarksville and Louisville Railroad. It was named for prominent U.S. diplomat James Gadsden (1788–1858), who was responsible for the Gadsden Purchase.
Gadsden is located at 35°46′38″N 88°59′26″W (35.777300, -88.990442). The town lies northeast of Jackson along a congruent stretch of U.S. Route 70 and U.S. Route 79. Tennessee State Route 221 intersects this highway toward the center of town. Humboldt lies to the northeast along US 79, and Bells lies to the southwest.
According to the United States Census Bureau, the town has a total area of 1.1 square miles (2.8 km2), all land.
As of the census of 2000, there were 553 people, 216 households, and 160 families residing in the town.