Galena is a city in Stone County, Missouri, United States. The population was 440 at the 2010 census. It is the county seat of Stone County. Galena is part of the Branson, Missouri Micropolitan Statistical Area.
Galena was platted in 1852, and named for deposits of the ore galena near the original town site. An early variant name was "Jamestown". A post office has been in operation at Galena since 1853. The last public execution in the United States took place in Galena in 1937.
According to the United States Census Bureau, the city has a total area of 0.76 square miles (1.97 km2), of which 0.75 square miles (1.94 km2) is land and 0.01 square miles (0.03 km2) is water. The James River flows past the east side of the town and enters the northernmost arm of Table Rock Lake to the south. The historic Y-Bridge over the James River is located just east of the town.