Gause is an unincorporated community in Milam County, Texas, United States. According to the Handbook of Texas, the community had an estimated population of 400 in 2000.
Gause is located at 30°47′07″N 96°43′17″W (30.7851923, -96.7213641 ). It is situated along U.S. Highway 79/190, sixteen miles southeast of Cameron and twenty-nine miles west of Bryan/College Station.
The community is named for William J. Gause, a settler who moved to the area in 1872 and built a home out of lumber hauled from Montgomery. In 1873, he gave right-of-way and 100 acres (0.40 km2) of land to the International-Great Northern Railroad (I&GN). This caused the area to grow and a post office opened in 1874. A schoolhouse that doubled as a church was built in 1876. Gause had approximately 300 residents in 1884 as well as two steam-powered cotton gins and two churches. Gause was a shipping point for Milam County farmers who shipped corn, cotton, and cottonseed oil. The Gause Independent School District was established in 1905.
The population reached its peak around 1915, when 1,000 people lived in the community.