Hartsville is a town in Haw Creek and Clifty townships, Bartholomew County, Indiana, United States. The population was 362 at the 2010 census. It is part of the Columbus, Indiana metropolitan statistical area.
Hartsville was founded in 1832. It was named for Gideon B. Hart, a pioneer settler. The first post office at Hartsville was established in 1838.
Hartsville is located at 39°16′1″N 85°41′55″W (39.267039, -85.698689).
According to the 2010 census, Hartsville has a total area of 0.34 square miles (0.88 km2), all land.
As of the census of 2010, there were 362 people, 132 households, and 98 families living in the town. The population density was 1,064.7 inhabitants per square mile (411.1/km2). There were 148 housing units at an average density of 435.3 per square mile (168.1/km2). The racial makeup of the town was 97.0% White, 1.1% African American, and 1.9% from two or more races. Hispanic or Latino of any race were 1.1% of the population.