Houston is a city in and one of two county seats of Chickasaw County, in northern Mississippi, United States. The population was 3,623 at the 2010 census.
Native American groups had long used the future Chickasaw County for millennia before the coming of European adventurers. Eventually the natives were essentially forced out of the area. An 1832 treaty finally made the area secure for settlement, and emigrants rapidly moved in. The formation of Chickasaw County was authorized on February 9, 1836, and a few days later a committee was authorized to determine the location of the county seat. Judge Joel Pinson offered to donate land for development of this seat, and on July 8, 1836 his offer was accepted. Judge Pinson named the settlement 'Houston' in memory of Sam Houston, a childhood friend.
Construction began that year on a brick courthouse on the village square, and a jail one block north. The city of Houston was incorporated on May 9, 1837, and its first Post Office was authorized on December 5 of that same year.