Monticello is a town in and the county seat of Lawrence County, Mississippi, United States. The population was 1,571 at the 2010 census.
Monticello is in central Lawrence County, on the west side of the Pearl River. U.S. Route 84 runs through the north side of the town on a four-lane bypass. US 84 leads east 15 miles (24 km) to Prentiss and west 22 miles (35 km) to Interstate 55 in Brookhaven. Mississippi Highway 27 passes through the west side of Monticello, leading north 37 miles (60 km) to Crystal Springs and south 33 miles (53 km) to Tylertown.
According to the United States Census Bureau, the town of Monticello has a total area of 4.2 square miles (11.0 km2), of which 4.2 square miles (10.8 km2) are land and 0.1 square miles (0.2 km2), or 2.17%, are water.
As of the census of 2000, there were 1,726 people, 690 households, and 451 families residing in the town. The population density was 530.4 people per square mile (205.1/km2). There were 754 housing units at an average density of 231.7 per square mile (89.6/km2). The racial makeup of the town was 64.19% White, 34.18% African American, 0.98% Asian, and 0.64% from two or more races. Hispanic or Latino of any race were 0.06% of the population.