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Mount Plymouth is an unincorporated community and census-designated place (CDP) in Lake County, Florida, United States. As of the 2010 census, the CDP population was 4,011, up from 2,814 in 2000. It is part of the Orlando–Kissimmee Metropolitan Statistical Area.
Mount Plymouth is located in eastern Lake County at 28°47′57″N 81°31′54″W. It is bordered to the south by the city of Apopka in Orange County. Florida State Road 46 passes through the center of the community, leading east 17 miles (27 km) to Sanford and west 7 miles (11 km) to Mount Dora. Tavares, the Lake county seat, is 12 miles (19 km) west of Mount Plymouth. Florida State Road 429, the Wekiva Parkway, passes east and south of Mount Plymouth, leading south around the west side of the Orlando area 42 miles (68 km) to Interstate 4.
According to the United States Census Bureau, the Mount Plymouth CDP has a total area of 3.1 square miles (7.9 km2), of which 2.9 square miles (7.5 km2) are land and 0.2 square miles (0.4 km2), or 4.91%, are water.
The Historic Mount Plymouth Hotel, built in 1926 at the cost of $350,000, was the centerpiece of a golfing resort for the area. The hotel became a center of activity in the area.