Myersville is a town in Frederick County, Maryland, United States. The population was 1,626 at the 2010 United States Census.
The town was incorporated in 1904.
On January 4, 1919, a large fire destroyed many shops and buildings in the center of town.
The Peter of P. Grossnickel Farm was listed on the National Register of Historic Places in 1998.
In October 2002, the Washington, D.C. metropolitan area snipers John Allen Muhammad and Lee Boyd Malvo who terrorized the region were apprehended at a rest stop along westbound I-70 in Myersville. The two were discovered when a truck driver recognized their car from police reports.
Myersville is located at 39°30′24″N 77°33′59″W (39.506627, -77.566271).
According to the United States Census Bureau, the town has a total area of 1.02 square miles (2.64 km2), all land. The Myersville area is the source of Catoctin Creek, which roughly flows in a "C" loop pattern (northside to eastside to southside) just outside the city limits.
The main method of transport to and from Myersville is by road. The main highway serving the town is Interstate 70, which heads eastward from Myersville to Baltimore and westward to Pittsburgh. Access to Myersville is provided via an interchange with Maryland Route 17, the other highway directly serving the town, which serves western Frederick County on a north–south alignment.