Pontotoc is a city in, and the county seat of, Pontotoc County, Mississippi, located to the west of the much larger city of Tupelo. The population was 5,625 at the 2010 census. Pontotoc is a Chickasaw word that means, “Land of the Hanging Grapes.”
Pontotoc is a Chickasaw word meaning "Land of Hanging Grapes". The Chickasaw nation occupied this area long before Europeans colonized the Southeast, the last in a succession of indigenous peoples who had this territory for thousands of years. In the early 1830s they were forced to Indian Territory west of the Mississippi River through the federal program of Indian removal.
In the late 19th century, the outlaws Jesse and Frank James and their gang came into this area. They once hid at an old house that had been used as a Union Army hospital during the Battle of Harrisburg or Battle of Tupelo in the Civil War. The house was located at a crossroad in east Pontotoc County, near the Lee County line.
The Town Square Museum is located in the historic US post office near the county courthouse. This space is used to house and display Pontotoc memorabilia.