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Modoc is an unincorporated community in Randolph County, Illinois, United States, located four miles southeast of Prairie du Rocher under the bluffs of the Mississippi River.
The Modoc Rock Shelter, a U.S. National Historic Landmark, is located near Modoc and the Ste. Genevieve-Modoc Ferry across the Mississippi River connects Modoc and the surrounding communities with Ste. Genevieve, Missouri.
The area's population was 221 at the 2000 census.
Modoc is located at 38°3′9″N 90°2′14″W (38.0525522 -90.0373334).
As of the 2000 census, there were 221 people, 96 households, and 61 families residing in Modoc's ZIP Code Tabulation Area (ZCTA). The racial makeup was 98.6% White and 1.4% from two or more races.
There were 96 households, out of which 29.2% had children under the age of 18 living with them, 55.2% were married couples living together, 6.3% had a female householder with no husband present, and 36.5% were non-families. 34.4% of all households were made up of individuals living alone, and 11.5% had someone living alone who was 65 years of age or older.