Tallassee (pronounced /ˈtæːləsi/) is a city on the Tallapoosa River, located in both Elmore and Tallapoosa counties in the U.S. state of Alabama. At the 2010 census the population was 4,819. It is home to a major hydroelectric power plant at Thurlow Dam operated by Alabama Power Company.
Tallassee is part of the Montgomery Metropolitan Statistical Area.
The historic Creek peoples in this area are believed to have descended from the Mississippian culture, which flourished throughout the Mississippi and Ohio river valleys and the Southeast from about 1000 to 1450. They were mound builders, who created massive earthwork mounds as structures for political and religious purposes. They relied greatly on fishing and riverway trading at their major sites (c.f. Moundville, Tuscaloosa).
Talisi (which means "Old Town" in the Creek language) was a town of the Coosa Province of the Mississippian culture; it was visited in 1540 by Hernando de Soto and his expedition through the Southeast. Later it was occupied by the historic Creek people.