Tellico Plains is a town in Monroe County, Tennessee, United States. The population was 859 at the 2000 census and 880 at the 2010 census.
The area along the Tellico River was inhabited for thousands of years by indigenous peoples. The historic Muscogee settled here, before moving further south. In the late 18th century, the Cherokee settled in this area, displaced from the east and north by European colonial encroachment.
Tellico Plains occupies the former site of the Cherokee town of Great Tellico, which was one of the more important towns of the Overhill Cherokee during the late 18th century and before Indian Removal of the 1830s. Two important Native American trails met at Great Tellico, the Trading Path and the Warrior Path, which connected farflung communities.
European Americans moved into the area and developed the land for agriculture, chiefly subsistence farming. During the 1840s, Elisha Johnson, a former mayor of Rochester, New York, purchased a plantation here and built the Tellico River Mansion on his property. With his brother Ebenezer, the former mayor of Buffalo, New York, he purchased the Tellico Iron and Manufacturing Company.
During the Civil War, the Confederacy commandeered the iron works for production of munitions.