Tuscola is a city in Taylor County, Texas, United States. The population was 742 at the 2010 census. It is part of the Abilene, Texas Metropolitan Statistical Area.
Tuscola is located at 32°12′33″N 99°47′50″W (32.209060, -99.797126).
According to the United States Census Bureau, the city has a total area of 0.7 square miles (1.9 km2), all of it land.
The climate in this area is characterized by hot, humid summers and generally mild to cool winters. According to the Köppen climate classification system, Tuscola has a humid subtropical climate, Cfa on climate maps.
As of the census of 2000, there were 714 people, 273 households, and 202 families residing in the city. The population density was 971.2 people per square mile (372.5/km2). There were 307 housing units at an average density of 417.6 per square mile (160.2/km2). The racial makeup of the city was 97.20% White, 0.14% African American, 0.28% Native American, 0.14% Asian, 0.70% from other races, and 1.54% from two or more races. Hispanic or Latino of any race were 7.28% of the population.