Van Alstyne is a city in Grayson and Collin Counties in the U.S. state of Texas. The population was 3,046 at the 2010 census, up from 2,502 at the 2000 census. The Grayson County portion of Van Alstyne is part of the Sherman–Denison Metropolitan Statistical Area.
Van Alstyne was built in 1872, for settlers to be near the railroad stop of the Houston and Texas Central Railway. The town was named for either William A. Van Alstyne, a civil engineer with the railroad, or for Marie Van Alstyne, a shareholder in the railroad company.
The town was incorporated in 1890.
Per a Van Alstyne Leader newspaper article September 3, 2015 the Outlaw "Bushwhacker Bill" Wilson, on whom the Clint Eastwood movie The Outlaw Josey Wales is based, was murdered somewhere in the vicinity of either the intersection of Texas Hwy 5 and Prong Creek 1 mile North of Van Alstyne or South of Van Alstyne halfway to the old ghost town of Mantua.
Van Alstyne is located in southeastern Grayson County at 33°25′26″N 96°34′43″W (33.423911, -96.578730). The city limits extend south slightly into Collin County.
The U.S. Route 75 freeway runs through the western side of the city, with access from Exits 50 and 51. US 75 leads north 27 miles (43 km) to Denison and south 50 miles (80 km) to the center of Dallas. Van Alstyne's immediate neighbors are Anna to the south and Howe to the north.