Wellsville is a village in Columbiana County, Ohio, United States, along the Ohio River. The population was 3,541 at the 2010 census. Wellsville is the southernmost point of the Salem, OH Micropolitan Statistical Area, as well as the greater Mahoning Valley.
In 1770, George Washington with his friend and personal surveyor, William Crawford, embarked on a journey down the Ohio River from Pittsburgh for the purpose of viewing lands to be apportioned among soldiers who had served in the French and Indian War. They are reported to have surveyed the Wellsville area, just north of Yellow Creek in 1770 and noted in his journal that it was good bottom land.
The Yellow Creek Massacre occurred near Wellsville in 1774. A group of Virginian settlers killed the relatives of a prominent Iroquois leader, Logan, who was camped on Yellow Creek. Logan took revenge, resulting in Lord Dunmore's War.
James Clark and William Wells first settled in the area in 1795. Although they had to leave for a while due to Native American attacks in the area, they returned between 1797 and 1800.