Woodruff is a city in Spartanburg County, South Carolina, United States, located in the "Upstate" area. The population was 4,101 at the 2010 census.
Woodruff is located at 34°44′26″N 82°1′57″W (34.740530, -82.032580).
According to the United States Census Bureau, the city has a total area of 3.7 square miles (9.6 km2), of which 0.04 square miles (0.10 km2), or 0.54%, is water.
The Earliest History of this area begins with the membership of “The Church of Christ on Jamey’s Creek” dated September 18, 1787. The church was so called as this was the nearest point of designation since “Jamey’s Creek” heads of McArthur Street behind the Woodruff State Branch Bank on North Main Street. The creek is now called “Jimmie’s Creek”. The early members traveled some distance to attend this church. They were from the communities of Cavins, Enoree, Crescent, Switzer and even others in Laurens County. Most of the early settlers had come from Virginia and North Carolina. They were primarily veterans of the Revolution and their families. Joseph Woodruff received a grant of 200 acres (which would later become Woodruff, S.C.).