Andrews is a town in Georgetown and Williamsburg counties in the U.S. state of South Carolina. The population was 2,861 at the 2010 census, down from 3,068 in 2000. General aviation airfield Robert F. Swinnie Airport is located 2 miles (3 km) east of the central business district.
Andrews is located in western Georgetown County, with a small portion extending west into Williamsburg County. U.S. Route 521 bypasses the town to the south, then passes through the west side of the town; the highway leads northwest 62 miles (100 km) to Sumter and east 17 miles (27 km) to Georgetown, the county seat. South Carolina Highway 41 leads northeast 24 miles (39 km) to Hemingway and southwest 15 miles (24 km) to Jamestown. Charleston is 59 miles (95 km) to the southwest.
According to the United States Census Bureau, Andrews has a total area of 2.2 square miles (5.7 km²), all land.
As of the census of 2000, there were 3,068 people, 1,182 households, and 843 families residing in the town. The population density was 1,392.6 people per square mile (538.4/km²). There were 1,347 housing units at an average density of 611.4 per square mile (236.4/km²).