Appleton is a city in Outagamie (mostly), Calumet, and Winnebago counties in the U.S. state of Wisconsin. One of the Fox Cities, it is situated on the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. Appleton is the county seat of Outagamie County. The population was 72,623 at the 2010 census. Of this figure, 60,045 resided in Outagamie County, 11,088 in Calumet County, and 1,490 in Winnebago County. Appleton is the principal city of the Appleton, Wisconsin Metropolitan Statistical Area, which is included in the Appleton-Oshkosh-Neenah Combined Statistical Area, the third largest in the state behind Milwaukee and Madison.
Appleton serves as the heart of the Fox River Valley, and is home to the Fox Cities Exhibition Center, Fox Cities Performing Arts Center, Fox River Mall, Neuroscience Group Field at Fox Cities Stadium, Appleton International Airport, and the Valley's two major hospitals: St. Elizabeth Hospital and ThedaCare Regional Medical Center–Appleton (better known as "Appleton Medical Center"). It also hosts many regional events such as its Flag Day parade, Memorial Day parade, Christmas parade, Octoberfest, Mile of Music, and others.
The territory where Appleton is today was traditionally occupied by the Ho-Chunk and the Menominee.