Bluffton is a Lowcountry town in Beaufort County, South Carolina, United States. It is primarily located around U.S. Route 278, between Hilton Head Island and Interstate 95. The town's original one square mile area, now known as Old Town, is situated on a bluff along the May River. The population was counted by the 2010 census at 12,893, and was estimated to have swelled to 25,557 in 2019. Additionally, it is the fastest growing municipality in South Carolina with a population over 2,500, growing 882.7% between the 2000 and 2010 census. Bluffton is the fifth largest municipality in South Carolina by land area. The town is a primary city within the Hilton Head Island-Bluffton-Beaufort, SC Metropolitan Statistical Area.
Following the Tariff of 1842, Bluffton became a hotbed of separatist sentiment. In 1844 the Bluffton Movement, a protest against federal taxes, gave birth to the secession movement and led South Carolina to be the first state to leave the Union. In the antebellum period Bluffton became a popular location for wealthy merchants and plantation owners.