Center Ossipee is a census-designated place in the town of Ossipee in Carroll County, New Hampshire. The population was 561 at the 2010 census. It is one of two major villages in the town, the other being Ossipee Corner (shown simply as "Ossipee" on topographic maps). Center Ossipee has a separate ZIP code (03814) from other portions of the town of Ossipee.
The CDP is in the east-central part of the town of Ossipee, on high ground north of the Dan Hole River and southwest of Ossipee Lake. New Hampshire Route 16 and Route 25 bypass the village to the east. Route 16 leads south 6 miles (10 km) to Ossipee village and 36 miles (58 km) to Rochester; to the north it leads six miles to West Ossipee and 27 miles (43 km) to North Conway. Route 25 runs north with Route 16 but turns west to Meredith, 28 miles (45 km) from Center Ossipee. To the east Route 25 leads 53 miles (85 km) to Portland, Maine.
According to the U.S. Census Bureau, the Center Ossipee CDP has a total area of 0.97 square miles (2.5 km2), all of it recorded as land.
As of the census of 2010, there were 561 people, 229 households, and 139 families residing in the CDP. There were 256 housing units, of which 27, or 10.5%, were vacant.