Chamberlain (Lakota: makȟáthipi; "earth dwelling") is a city in Brule County, South Dakota, United States. It is located on the eastern bank of the Lake Francis Case dammed section of the Missouri River, close to where it is crossed by Interstate 90.
The population of Chamberlain was 2,387 at the 2010 census. It is the county seat of Brule County.
Chamberlain is home to the South Dakota Hall of Fame, and St. Joseph's Indian School, a Native American residential school run by the Catholic Priests of the Sacred Heart. The 50-foot (15 m) sculpture of a Native American woman, Dignity, overlooks the Missouri River on a bluff outside the city.
Chamberlain was named after Selah Chamberlain, a railroad director of the Chicago, Milwaukee and St. Paul Railway.
Chamberlain is located at 43°49′20″N 99°19′42″W (43.805548, -99.328444).
According to the United States Census Bureau, the city has a total area of 7.84 square miles (20.31 km2), of which 6.64 square miles (17.20 km2) is land and 1.20 square miles (3.11 km2) is water.
Chamberlain has been assigned the ZIP code range 57325-57326 and the FIPS place code 11220.
As of the census of 2010, there were 2,387 people, 1,040 households, and 589 families living in the city. The population density was 359.5 inhabitants per square mile (138.8/km2).