Clewiston is a city in Hendry County, Florida, United States. Its location is 80 miles (130 km) northwest of Fort Lauderdale on the Atlantic coastal plain. The population was 7,155 at the 2010 census, up from 6,460 at the 2000 census. The estimated population in 2018 was 7,985. The city is located on the south bank of Lake Okeechobee, and the Lake Okeechobee Scenic Trail (LOST) passes through the edge of the city. The city is home to Billie Swamp Safari, the Clewiston Museum and the Dixie Crystal Theatre. The area has been home to Seminole tribe members and sugar plantations, with the Ah-Tah-Thi-Ki Seminole Indian Museum located 32 miles (51 km) south of the city.
The area beside Lake Okeechobee was once used as a fishing camp by the Seminole tribe. The first permanent settlement began in 1920, when John O'Brien of Philadelphia and Alonzo Clewis of Tampa purchased a large tract of land to establish a town. They commissioned a town plan and built the Moore Haven & Clewiston Railway to connect the community to the Atlantic Coast Line Railroad at Moore Haven.