Du Quoin ( doo-KOYN) is a city in Perry County, Illinois, United States. The population was 6,109 at the 2010 census.
Du Quoin is located at 38°0′N 89°14′W (38.0068, -89.2349).
The city of Du Quoin is located in the southeastern portion of Perry County, Illinois.
According to the 2010 census, Du Quoin has a total area of 7.061 square miles (18.29 km2), of which 6.98 square miles (18.08 km2) (or 98.85%) is land and 0.081 square miles (0.21 km2) (or 1.15%) is water.
The area east of Du Quoin is known as "Old Du Quoin." In the early 19th century, Du Quoin was near the Lusk's Ferry Road, an important early road that connected Kaskaskia with Lusk's Ferry on the Ohio River. The road ran easterly out of Steeleville to a point southwest of DuQuoin. There it turned to the southeast to cross the Big Muddy River and head for Lusk's Ferry.
Du Quoin had its start at its present location in 1853 when the railroad was extended to that point. The city was named after Chief Jean Baptiste Ducoigne of the Kaskaskia, an Illiniwek people, who were defeated by the Shawnee near here in 1802.
Du Quoin is served by a daily newspaper, the Du Quoin Call as well as a weekly newspaper, the Weekly-Press. Du Quoin is also served by radio stations WDQN AM 1580/FM 97.1 and WDQN-FM 95.9 FM.
Amtrak, the national passenger rail system, provides service to Du Quoin.