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East Pepperell is a census-designated place (CDP) in the town of Pepperell in Middlesex County, Massachusetts, United States. The population was 2,059 at the 2010 census.
Like the town of Pepperell, East Pepperell is named for Sir William Pepperrell, a Massachusetts colonial soldier who led the Siege of Louisbourg during King George's War.
East Pepperell is located at 42°40′1″N 71°33′51″W (42.666956, -71.564063).
According to the United States Census Bureau, the CDP has a total area of 3.8 km2 (1.5 mi2). 3.7 km2 (1.4 mi2) of it is land and 0.1 km2 (0.04 mi2) of it (2.76%) is water.
As of the census of 2000, there were 2,034 people, 714 households, and 566 families residing in the CDP. The population density was 557.0/km2 (1,437.7/mi2). There were 722 housing units at an average density of 197.7/km2 (510.3/mi2). The racial makeup of the CDP was 96.21% White, 0.84% African American, 0.20% Native American, 0.39% Asian, 0.69% from other races, and 1.67% from two or more races. Hispanic or Latino of any race were 1.18% of the population.
There were 714 households, out of which 43.4% had children under the age of 18 living with them, 58.5% were married couples living together, 17.4% had a female householder with no husband present, and 20.6% were non-families. 16.1% of all households were made up of individuals, and 4.1% had someone living alone who was 65 years of age or older.