Greenbrier is a city in Faulkner County, Arkansas, United States. It is part of the Little Rock–North Little Rock–Conway Metropolitan Statistical Area. The population was 4,706 at the 2010 census, up from 3,042 at the 2000 census.
Prior to European settlement, Native American tribes, including the Quapaw and later the Cherokee, lived in the area. Several historical figures of the Wild West such as Jim Bowie and Jesse James passed through the Greenbrier region toward Oklahoma and Texas. The Wiley brothers settled near East Fork Cadron around 1818, about 8 miles (13 km) east of today's Greenbrier. In 1837, Jonathan Hardin settled near the Wiley settlement. Also in the early 19th century, the Casharagos settled north of Greenbrier in the present community of Republican.
Greenbrier is a town that developed from a minor brothel on the Butterfield Stagecoach route into a bustling city. The town was named for the greenbriar vines which grew along the creek through the town.