Greenwood is a city in and the county seat of Greenwood County, South Carolina, United States. The population was 23,222 at the 2010 census. The city is home to Lander University.
Greenwood is located slightly northwest of the center of Greenwood County. According to the United States Census Bureau, the city has a total area of 16.3 square miles (42.3 km2), of which 16.2 square miles (42.0 km2) are land and 0.1 square miles (0.3 km2), or 0.72%, are water.
U.S. Routes 25, 178 and 221 pass through the eastern side of the city, bypassing the downtown area. US 25 leads north 51 miles (82 km) to Greenville and south 63 miles (101 km) to Augusta, Georgia, US 178 leads northwest 42 miles (68 km) to Anderson and southeast 29 miles (47 km) to Saluda, and US 221 leads northeast 26 miles (42 km) to Laurens and southwest 23 miles (37 km) to McCormick.
Lake Greenwood, a reservoir on the Saluda River, is 8 miles (13 km) northeast of the city at its nearest point. The lake has 212 miles (341 km) of shoreline, covers 11,000 acres (4,500 ha), and is almost 20 miles (32 km) long. Lake Greenwood State Park, built in the 1930s by the Civilian Conservation Corps, is 14 miles (23 km) east of the city on the south shore of Lake Greenwood and includes two boat ramps, a campground, trail and playgrounds, and many picnic areas. The area around Greenwood is locally billed as the "Lakelands", due to several lakes for recreational fishing and diverse terrain for hiking trails.
As of the census 2000, there were 22,071 people, 8,496 households, and 5,174 families residing in the city.