Guadalupe is a town in Maricopa County, Arizona, United States. Since its founding, Guadalupe has been known as a center of Yaqui culture and it is home to many religious festivals. The town motto, "where three cultures flourish," recognizes the town's roots in the Yaquis, Mexicans and descendants of the original farmers. Nestled between Phoenix and Tempe, the 2010 census listed the population of the town as 5,523. Guadalupe was founded around 1900 by Yaqui Indians, who fled their homeland in Sonora to avoid oppression by the Mexican government of Diaz. The cemetery of Guadalupe was established in 1904, in the original townsite of the town. The city of Tempe annexed the area surrounding the cemetery. The cemetery is now officially located in Tempe; however, it is still administered by the Guadalupe Clerk's Office. Guadalupe is primarily a residential area; most residents commute to other parts of the Phoenix area to work.
Guadalupe is located at 33°22′0″N 111°57′45″W (33.366733, -111.962414).
According to the United States Census Bureau, the town has a total area of 0.8 square miles (2.1 km2), all land.
As of the census of 2000, there were 5,228 people, 1,110 households, and 961 families residing in the town.