Harrisburg is a city in Lincoln County, South Dakota, United States and is a suburb of Sioux Falls. The population was 4,089 by the 2010 census, having grown from 958 in 2000 census. The population of the Harrisburg zip code has grown from 2,476 in 2000 to 10,342 in 2010.
Before the railroad was built through Lincoln County, a stagecoach brought mail to the Johnson Harris Homestead located on Nine Mile Creek in Dayton Township. Johnson Harris named the post office Harrisburg in honor of himself.
The history of Harrisburg started August 1, 1879, when the first train came rolling through the territory. The train went from Sioux City, Iowa, to Sioux Falls, South Dakota. The post office was moved to the Emory J. Darling Homestead, 1 mile south of what is now Harrisburg. The post office was called Salina in honor of Mrs. Jim Stillwell, an early settler and a highly respected teacher.
Finally in 1890, the depot was moved to its present site. The post office took back its original name and the town of Harrisburg was born.