Hartsville is the largest city in Darlington County, South Carolina, United States. It was chartered on December 11, 1891. The population was 7,764 at the 2010 census. Hartsville was chosen as an All-America City in 1996 and again in 2016. Hartsville has also been a National Arbor Day Foundation Tree City since 1986.
Hartsville is home of Coker College and a branch of Florence–Darlington Technical College. It is also the home of the South Carolina Governor's School for Science and Mathematics, a public boarding high school.
The city is served by the Hartsville Regional Airport.
Hartsville is home to several major corporations including Sonoco Products Company, Duke Energy's H. B. Robinson Nuclear Generating Station, Novolex, and Stingray Boats.
The area surrounding Hartsville was once home to several Native American tribes, including the Pee Dee, Catawba, Chicora, Edisto, Sane, and Chicora-Waccamaw, who inhabited the region until European settlers arrived.